Anything but spiders.
I hate spiders - I know that's not a manly thing to say, but I do. I hate them. I can handle blood, I take boxing lessons, I'm a guy's guy (used to remodel houses), but no spiders. I saw Charlotte's Web as a child and all I could think was, will someone get some bug spray and end this charade. Even if you were to put a cute over sized baseball hat on a spider, give him the voice of the puppy from the fabric softener commercials, and put him in some kind of narrative where he gets picked last in a kickball game and teased by all the other mean spiders, I would still mush his ass with a Kleenex (attached to a long stick (attached to an even longer stick)) without hesitation.
I have no other creative restrictions.